Department of Pharmaceutical Sciences and Biotechnology
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Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein
(Nature Research, 2024-06-03)A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV) has previously been shown to protect goats from challenge with wild-type ... -
Designing a multiplex PCR-xMAP assay for the detection and differentiation of African Horse Sickness virus, Serotypes 1–9
(MDPI, 2024-05-03)African horse sickness is a severe and often fatal disease affecting all species of equids. The aetiological agent, African horse sickness virus (AHSV), can be differentiated into nine serotypes. The identification of ... -
Association of feed efficiency with organ characteristics and fatty liver haemorrhagic syndrome in laying hens
(Nature Reports, 2023-04-11)Poor feed efficiency (FE) in hens impacts body weight (BW) and may reflect suboptimal health. Fatty Liver Haemorrhagic Syndrome (FLHS) is mostly observed in laying hens and affects egg production and hen performance. The ... -
In silico screening of phytochemicals from Dissotis rotundifolia against Plasmodium falciparum Dihydrofolate Reductase.
(Elsevier, 2023-04-01)Background: Malaria remains a major health concern in developing countries with high morbidity and mortality, especially in pregnant women and infants. A major obstacle to the treatment of malaria is a low effectiveness ... -
Effectiveness of front line and emerging fungal disease prevention and control interventions and opportunities to address appropriate eco-sustainable solutions
(Elsevier, 2022-08-21)Fungal pathogens contribute to significant disease burden globally; however, the fact that fungi are eukaryotes has greatly complicated their role in fungal-mediated infections and alleviation. Antifungal drugs are often ... -
Insights into the mechanisms of Cronobacter sakazakii virulence
(Elsevier, 2022-06)Cronobacter species have adapted to survive harsh conditions, particularly in the food manufacture environment, and can cause life-threatening infections in susceptible hosts. These opportunistic pathogens employ a multitude ... -
An investigation of the in vitro effects of unconjugated linoleic acid and its potential impact on haemostasis
(Athlone Institute of Technology, 2021-04)Introduction: Linoleic acid, an essential ω6 fatty acid, is the most abundant polyunsaturated fatty acid in the Western mammalian diet. Linoleic acid has been linked with an increased inflammatory response. It has also ... -
An investigation into critical factors influencing ecosystem dynamics in fish rearing water and disease mitigation eco-innovations for the enhancement of Irish freshwater aquaculture
(Athlone Institute of Technology, 2020)Aims and Rationale: The aquaculture sector is becoming the fastest growing food sector in the world, with an increasing requirement for higher production rates. With the maximum sustainable yield almost exhausted in terms ... -
Investigation into the novel application & utilisation of algae to aid in developing sustainable Irish freshwater aquaculture
(Athlone Institute of Technology, 2021-06)Aims and Rationale: Aquaculture is the fastest growing food producing industry in the world producing >50% of the world’s seafood. Food Wise 2025, an initiative set by the Irish government to develop the Irish Agri-Food ... -
Monoamine modulators of herbal origin - Rhodiola rosea L.
(Technological University of the Shannon Midlands Midwest, 2022-01)Rhodiola rosea L. is a traditional herbal medicine used to relieve symptoms of fatigue, enhance mental performance and increase resistance to stress whilst promoting antidepressant, anxiolytic and neuroprotective ... -
Laccase oxidation studies: method development for following the benzyl alcohol oxidation reaction using the Laccase/TEMPO system
(Technological University of the Shannon Midlands Midwest, 2022)Biocatalysis is the use of nature’s biological catalysts – “enzymes” to perform synthetic chemical reactions, which are generally “greener” than traditional chemical methods. Laccases are a group of oxidoreductase enzymes ... -
Fingerprinting critical therapeutic attributes: overcoming challenges to fulfil commercial potential – Early stages
(Technological University of the Shannon Midlands Midwest, 2022)Aim: This research endeavour will determine and evaluate the mechanism of action of a modified coconut oil that has previously shown promising antimicrobial activity against the opportunistic infection, T. rubrum. Background: ... -
The medicinal properties of Irish honey
(Technological University of the Shannon Midlands Midwest, 2022)Manuka honey is an internationally recognized honey licensed as a medicinal product for wounds1 . Medicinal honeys are often used in hospitals for partial thickness burns2 to surgical wounds and in veterinary clinics ... -
Treatment for the amelioration of persistent factors in complex anal fistula
(Springer, 2021-11-19)Anal fistulae are abnormal hollow connections between the wall of the anal canal and the perianal skin around the anus that have remained a burden on the medical sector for centuries. The complexity of this disease is ... -
Application of biomaterials for complex anal fistulae
(Taylor & Francis, 2021-11-07)Complex anal fistulae remain a challenge for the medical sector as conventional treatments put patients at risk of incontinence. Clinicians and researchers have become interested in the application of bioresorbable ... -
Researching ways to combat the negative effects of pathogen spillover for commercial bees and products
(Athlone Institute of Technology, 2020-06)Bees pollinate over 80% of the agricultural crops produced in Europe. Honey Bees (Apis mellifera) are used as a commercial pollinator for many agricultural crops globally(Commission, 2018). However there is evidence that ... -
The development of novel bioresorbable medical devices for treating diseases of the anal canal
(Athlone Institute of Technology, 2020-06)Anal abscesses and fistulae in ano are the most prominent diseases of the anal canal Abscesses are pockets of pus caused by accumulating bactera whereas fistulae in ano are hollow tunnels that protrude from the wall of ... -
Single nucleotide polymorphisms in the growth hormone and insulin-like growth factor-1 genes are associated with milk production, body condition score and fertility traits in dairy cows.
(GMR, 2011-08-26)The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to ... -
DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits
(BMC, 2011-01-11)Background: Genes which are epigenetically regulated via genomic imprinting can be potential targets for artificial selection during animal breeding. Indeed, imprinted loci have been shown to underlie some important ... -
DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.
(BMC, 2010-10-13)Background: Studies in mice and humans have shown that imprinted genes, whereby expression from one of the two parentally inherited alleles is attenuated or completely silenced, have a major effect on mammalian ...
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