Browsing Department of Pharmaceutical Sciences and Biotechnology by Title
Now showing items 1-20 of 72
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Accelerated solvent based extraction and enrichment of selected plasticisers and 4-nonylphenol, and extraction of tin from organotin sources in sediments, sludges and leachate soils.
(Elsevier, 2009-02-23)Enrichment techniques have become an important feature in the trace analysis of oestrogen mimicking chemicals in the environment. Recent developments such as accelerated solvent extraction (ASE) have improved extraction ... -
Advanced therapies and the outer limits of DNA regulation: new horizons for patents or a scaffold too far?
(Oxford Academic, 2008-04)This Regulation seeks to regulate existing and future advanced therapy medicinal products intended for the market in Member States, being either prepared industrially or manufactured by a method involving an industrial ... -
Analysis of bio-obtainable endocrine disrupting metals in river water and sediment, sewage influent/effluent, sludge, leachate, and concentrated leachate, in the Irish Midlands Shannon catchment.
(Hindawi, 2009-12)The application of an acid digestion and subsequent solid-phase extraction (SPE) procedure were implemented as preliminary treatments prior to quantifying the levels of potentially endocrine disrupting metals (EDMs) in a ... -
Analytical characterization and pharmacological evaluation of the new psychoactive substance 4-fluoromethylphenidate (4F-MPH) and differentiation between the (±)-threo- and (±)-erythro- diastereomers
(Wiley, 2017-03)Misuse of (±)-threo-methylphenidate (methyl-2-phenyl-2-(piperidin-2-yl)acetate; Ritalin®; MPH) has long been acknowledged, but the appearance of MPH analogs in the form of 'research chemicals' has only emerged in more ... -
Application of biomaterials for complex anal fistulae
(Taylor & Francis, 2021-11-07)Complex anal fistulae remain a challenge for the medical sector as conventional treatments put patients at risk of incontinence. Clinicians and researchers have become interested in the application of bioresorbable ... -
Association of feed efficiency with organ characteristics and fatty liver haemorrhagic syndrome in laying hens
(Nature Reports, 2023-04-11)Poor feed efficiency (FE) in hens impacts body weight (BW) and may reflect suboptimal health. Fatty Liver Haemorrhagic Syndrome (FLHS) is mostly observed in laying hens and affects egg production and hen performance. The ... -
Associations between the K232A polymorphism in the diacylglycerol-O-transferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle
(Teagasc, 2010)Selection based on genetic polymorphisms requires accurate quantification of the effect or association of the polymorphisms with all traits of economic importance. The objective of this study was to estimate, using progeny ... -
Characterisation and toxicological evaluation of hydrogel-type polymeric biomatrials pre-and poststerilisation with a novel pulsed plasma gas-discharge system.
(Athlone Institute of Technology, 2010)This study investigated the in vitro biocompatibility and important physicochemical properties of unique N-vinyl-2-pyrrolidone–acrylic acid based copolymer hydrogels intended for use in biomedical applications. Moreover, ... -
Characterisation of biopharmaceuticals
(The Institute of Chemistry of Ireland, 2016-07)Biopharmaceuticals are drugs which are primarily (glyco)protein in nature, that are produced in living cells using recombinant DNA technology – the combination of genetic material from multiple sources, creating sequences ... -
Comparative activity of silver based antimicrobial composites for urinary catheters.
(Elsevier, 2018-08-18)Biomedical polymers are an integral component in a wide range of medical devices because of their many desirable properties. However, extensive use of polymer materials in medical devices has been associated with an ... -
Designing a multiplex PCR-xMAP assay for the detection and differentiation of African Horse Sickness virus, Serotypes 1–9
(MDPI, 2024-05-03)African horse sickness is a severe and often fatal disease affecting all species of equids. The aetiological agent, African horse sickness virus (AHSV), can be differentiated into nine serotypes. The identification of ... -
The detection of endocrine disrupting chemicals leaching from reusable plastic water bottles.
(Athlone Institute of Technology, 2016)Endocrine disruption is a particular form of toxicity, where natural and/or endogenous compounds, known as “Endocrine Disrupting Chemicals”, cause adverse health effects by resulting in disruption to the endogenous hormone ... -
Detection, toxicology, environmental fate and risk assessment of nanoparticles in the aquatic environment (DeTER)
(EPA, 2018)Nanotechnology is an emerging technology that has the potential to impact on all aspects of life and the economy and is expected to form the basis of several technological innovations and advances in the 21st century. ... -
Determination of the effect of dairy powders on adherence of Streptococcus sobrinus and Streptococcus salivarius to hydroxylapatite and growth of these bacteria
(Elsevier, 2011-06-12)Dental caries is a highly prevalent disease caused by colonisation of tooth surfaces by cariogenic bacteria, such as Streptococcus sobrinus and Streptococcus salivarius. Reducing initial adherence of such bacteria to teeth ... -
The development of novel bioresorbable medical devices for treating diseases of the anal canal
(Athlone Institute of Technology, 2020-06)Anal abscesses and fistulae in ano are the most prominent diseases of the anal canal Abscesses are pockets of pus caused by accumulating bactera whereas fistulae in ano are hollow tunnels that protrude from the wall of ... -
DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.
(BMC, 2010-10-13)Background: Studies in mice and humans have shown that imprinted genes, whereby expression from one of the two parentally inherited alleles is attenuated or completely silenced, have a major effect on mammalian ... -
DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits
(BMC, 2011-01-11)Background: Genes which are epigenetically regulated via genomic imprinting can be potential targets for artificial selection during animal breeding. Indeed, imprinted loci have been shown to underlie some important ...
