Articles - Bioscience Research Institute (BRI)
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Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens
(Elsevier, 2023-12-02)Mycobacterium tuberculosis, the causative agent of human tuberculosis (hTB), is a close evolutionary relative of Mycobacterium bovis, which causes bovine tuberculosis (bTB), one of the most damaging infectious diseases to ... -
Development of a novel recirculatory multitrophic peatland system for the production of high-value bio-based products at scale embracing zero waste and pollution principles to unlock sustainable development goals
(Elsevier, 2024-06)This case study describes the novel development and demonstration of commercial, green, bio-based products using a peatland based recirculating integrated multi-trophic aquaculture (IMTA) system in the Irish Midlands. This ... -
Quo vadis - development of a novel peatland-based recirculating aquaculture mutli-trophic pond system (RAMPS) in the Irish midlands with a global orientation.
(Elsevier, 2024-05-03)Development of peatland-based, recirculating freshwater aquaculture that is efficient and economically viable presents considerable benefits for society including supporting communities transitioning to low-carbon ... -
Synergy assessment of four antimicrobial bioactive compounds for the combinational treatment of bacterial pathogens
(MDPI, 2023-08-07)Antimicrobial resistance (AMR) has become a topic of great concern in recent years, with much effort being committed to developing alternative treatments for resistant bacterial pathogens. Drug combinational therapies ... -
In Vivo Imaging Sheds Light on the Susceptibility and Permissivity of Carassius auratus to Cyprinid Herpesvirus 2 According to Developmental Stage
(MDPI, 2023-08-15)Cyprinid herpesvirus 2 (CyHV-2) is a virus that causes mass mortality in economically important Carassius spp. However, there have been no comprehensive studies into host susceptibility or permissivity with respect to ... -
An in vitro and in silico investigation of the antitrypanosomal activities of the stem bark extracts of Anopyxis klaineana (Pierre) Engl
(Cell Press, 2024-03-16)African Trypanosomiasis caused by trypanosome parasites continues to be a major neglected health problem, particularly in developing countries. Current treatments are marked by serious side effects, low effectiveness, ... -
In silico identification of potential PvFKBP35 inhibitors from Entadrophragma angolense Limonoids extracts as antimalarial agents
(Elsevier, 2023-08-05)Plasmodium species, which are spread by female Anopheles mosquitoes, are responsible for malaria. Out of the five major Plasmodium species, Plasmodium falciparum and Plasmodium vivax are the most deadly and invasive species ... -
Bioprocessing and the production of antiviral biologics in the prevention and treatment of viral infectious disease
(MDPI, 2023-05-17)Emerging, re-emerging and zoonotic viral pathogens represent a serious threat to human health, resulting in morbidity, mortality and potentially economic instability at a global scale. Cer tainly, the recent emergence ... -
Modification of hyaluronic acid to enable click chemistry photo-crosslinking of hydrogels with tailorable degradation profiles
(Elsevier, 2023-06-15)Hyaluronic acid (HA) is a naturally occurring mucopolysaccharide that, due to its inherent bioactivity and extracellular matrix-like structure, has the potential to be utilised extensively in tissue engineering. However, ... -
Role of ascomycete and basidiomycete fungi in meeting established and emerging sustainability opportunities: a review
(Taylor & Francis, 2023-04-27)Fungal biomass is the future’s feedstock. Non-septate Ascomycetes and septate Basidiomycetes, famously known as mushrooms, are sources of fungal biomass. Fungal biomass, which on averagely comprises about 34% protein ... -
Performance of Biomass and Exopolysaccharide Production from the Medicinal Mushroom Ganoderma lucidum in a New Fabricated Air-L-Shaped Bioreactor (ALSB)
(MDPI, 2023-02-22)Conventional stirred-tank bioreactor (STR) designs are optimised for cultures of bacteria but not fungal cultures; therefore, a new Air-L-Shaped Bioreactor (ALSB) was fabricated. The ALSB was designed to eliminate the wall ... -
Editorial: "The value of microbial bioreactors to meet challenges in the circular bioeconomy".
(Frontiers, 2023-04-05)The use of microbial bioreactors has harnessed immense attention to support many of the United Nation’s Sustainable Development Goals where this innovative platform provides crucial insights into unlocking a diversity ... -
A review of Spaulding's classification system for effective cleaning, disinfection and sterilization of reusable medical devices: viewed through a modern-day lens that will inform and enable future sustainability
(Elsevier, 2023-03-22)Despite advances in medicine and innovations in many underpinning fields including disease prevention and control, the Spaulding classification system, originally proposed in 1957, remains widely used for defining the ... -
Studies on the comparative effectiveness of x-rays, gamma rays and electron beams to inactivate microorganisms at different dose rates in industrial sterilization of medical devices
(Elsevier, 2023-03-17)The radiation resistance of Bacillus pumilus spores to gamma rays, X-rays, and electron beam (e-beam) was investigated using industrial irradiators operating at various dose rates. The dose rates were as follows: gamma ... -
Packaging environmental impact on seafood supply chains: a review of life cycle assessment studies
(Wiley, 2022)Packaging is fundamental for food preservation and transportation but generates an environmental burden from its production and end-of-life management. This review evaluates packaging contribution to the environmental ... -
Implications for the seafood industry, consumers and the environment arising from contamination of shellfish with pharmaceuticals, plastics and potentially toxic elements: a case study from Irish waters with a global orientation
(Elsevier, 2022-10-20)Shellfish are a rich source of minerals, B-vitamins and omega-3 to the human diet. The global population is expected to reach 9.6 billion people by 2050 where there will be increased demand for shellfish and for sustained ... -
A circular economy framework for seafood waste valorisation to meet challenges and opportunities for intensive production and sustainability
(Elsevier, 2023)There is a growing concern among societies and consumers over food security and the sustainability of food production systems. For seafood, it has been highly advocated as a healthy food source and its sustainability ... -
Pathogenic drug resistant fungi: a review of mitigation strategies
(MDPI, 2023-01-13)Fungal pathogens cause significant human morbidity and mortality globally, where there is a propensity to infect vulnerable people such as the immunocompromised ones. There is increasing evidence of resistance to antifungal ... -
Hallmarks of aging and immunosenescence: connecting the dots
(Elsevier, 2022-06)Aging is a natural physiological process that features various and variable challenges, associated with loss of homeostasis within the organism, often leading to negative consequences for health. Cellular senescence occurs ... -
A study of network intrusion detection systems using artificial intelligence/machine learning
(MDPI, 2022-11-18)The rapid growth of the Internet and communications has resulted in a huge increase in transmitted data. These data are coveted by attackers and they continuously create novel attacks to steal or corrupt these data. The ...
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